منابع مشابه
Endoreplication Cell Cycles More for Less
neatly aligned in parallel arrays (see Urata et al., 1995), but polytene chromosomes greater than 16,000C have been noted in another insect, Chironomus. The distinc-and various intermediate DNA configurations can occur, Seattle, Washington 98109 differing primarily in the degree of association between 2 Whitehead Institute and duplicated chromatids (Figure 2D, Hammond and Laird, Department of B...
متن کاملEndoreplication Controls Cell Fate Maintenance
Cell-fate specification is typically thought to precede and determine cell-cycle regulation during differentiation. Here we show that endoreplication, also known as endoreduplication, a specialized cell-cycle variant often associated with cell differentiation but also frequently occurring in malignant cells, plays a role in maintaining cell fate. For our study we have used Arabidopsis trichomes...
متن کاملChromosome Association of Minichromosome Maintenance Proteins in Drosophila Endoreplication Cycles
Minichromosome maintenance (MCM) proteins are essential eukaryotic DNA replication factors. The binding of MCMs to chromatin oscillates in conjunction with progress through the mitotic cell cycle. This oscillation is thought to play an important role in coupling DNA replication to mitosis and limiting chromosome duplication to once per cell cycle. The coupling of DNA replication to mitosis is a...
متن کاملGamma-Radiation Induced Endoreplication in Exposed CHO Cell Line
s: Several studies have highlighted the possibility of radiation induced chromosomal aberrations. The present study explains the susceptibility of numerical and structural chromosomal alterations, specifically endoreplication in irradiated Chinese Hamster Ovary (CHO) cell line. A total of 426 metaphase spreads prepared from CHO cells, exposed to 2 or 6 Gy of Co -rays were analyzed. The frequenc...
متن کاملEndoreplication: polyploidy with purpose.
A great many cell types are necessary for the myriad capabilities of complex, multicellular organisms. One interesting aspect of this diversity of cell type is that many cells in diploid organisms are polyploid. This is called endopolyploidy and arises from cell cycles that are often characterized as "variant," but in fact are widespread throughout nature. Endopolyploidy is essential for normal...
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ژورنال
عنوان ژورنال: Cell
سال: 2001
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(01)00334-8